How Do You Get Psoriasis?

Psoriasis is common in adults and is mostly linked to heredity. Some gene factors specifically the Interleukin-23 receptor and IL12B are involved in the generation of psoriasis. Other than these, some factors can trigger the symptoms and or even worsen the condition. These triggering factors include

Skin Laceration

Skin laceration can provoke psoriasis as the site of the wound and surrounding tissues may get affected by psoriasis. Prolonged untreated skin laceration or wound that is not curable within a certain time may increase the chances of psoriasis which is common with a diabetic patient.

Mental Stress

Mental stress due to occupational load or emotional anxiety accelerates the condition. An unbalanced lifestyle like excessive smoking and alcohol consumption aggravates the symptoms.

Environmental Factors

Seasonal changes can cause psoriasis, mainly dry, and less humid weather triggers the condition.

Chronic Infection

The sudden onset of psoriasis in early childhood is due to an infection caused by strep bacteria. A sore throat with a high fever is the symptom of this bacterial attack which initiates psoriasis. The chances of getting psoriasis with HIV positive person is more compared to HIV negative person.

Extensive Daytime Outdoor Activity

Prolonged exposure to sunlight damages the skin tissues. The harmful UV ray increases psoriasis, though morning sunlight is beneficial for treating psoriasis.

Pharmaceutical Products

Pharmaceutical products including painkillers (diclofenac, ibuprofen, and aspirin), sympatholytic medication especially beta-antagonistic medication (adrenalin), lithium (beryllium), calcium channel blockers (verapamil, diltiazem) and anti-malarial (quinidine, mefloquine) may cause psoriasis. Sometimes even withdrawing steroidal drugs worsen the situation.

Natural Cures for Psoriasis

Some natural psoriasis home remedies which are easily available and effective to fight psoriasis are discussed below:

Aloe vera

Mostly, all skin care natural products contain aloe vera. Traditionally aloe vera is used for treating different skin conditions and helps in improving skin health. Aloe vera extract is well established as a psoriasis home remedy and has even been scientifically proven to stop the frequent reoccurrence of psoriasis symptoms, restrict the conversion of mild to moderate or severe psoriasis, and even improve the severe condition.  It is better to obtain fresh aloe vera gel directly from the plant itself. The aloe vera plant is easily available, it is better to plant aloe vera in your garden. Freshly break the Horney leaf of aloe vera and locally apply the gel to the affected area. We already discussed that diabetic patients are more prone to psoriasis. Aloe vera juice help to lower blood sugar level and prevent psoriasis. Commercially, aloe vera gel and juice both are available in the market.

Turmeric

For improving skin complexion, turmeric is an age-old recipe. Evidence from different clinical studies and a specific publication reported in the journal ‘Advances in Experimental Medicine and Biology’ stated that turmeric is a better treatment for psoriasis. Turmeric can reduce skin cell proliferation and restrict unwanted skin tissue development which is the prime cause of psoriasis. Turmeric has anti-inflammatory and antiseptic properties due to the presence of curcumin, which is the active constituent of turmeric. Curcumin naturally boosts wound healing capacity by antagonizing the NF-kB which causes inflammation. For treating psoriasis, make a turmeric paste by thoroughly mixing it with water and thinly apply to the affected area. Cover the area with a piece of cloth and leave it overnight. In the morning, wash it with warm water. It is also advisable to add turmeric to your diet; if possible, consuming raw turmeric or turmeric juice gives better results. Turmeric is one of the most popular psoriasis home remedies.

ACV (Apple Cider Vinegar)

ACV is a good psoriasis treatment, as it alters the Ph level of the blood. The amazing fact about ACV is that though it is acidic by metabolism, it increases the Ph level and turns to alkaline. It is always preferable to eat alkaline food in case of a psoriasis attack. Drink apple cider vinegar which acts against the scaly skin of psoriasis. Topical application also reduces the itching symptoms. Direct application of ACV at the affected area with hot condensation is useful, as the acidic solution counteracts the itching.

Sandalwood Pack

From ancient times sandalwood is an effective treatment for skin problems. Psoriasis symptoms can be controlled by a sandalwood pack. To prepare this pack, you have to take one teaspoonful of sandalwood and one teaspoonful of camphor powder. Mix both these powders with rose water and prepare a consistent pack that is easily applicable to the skin. Topical application at the affected site gives a cooling and soothing effect and reduces irritation. This is one of the exclusive psoriasis home remedies.

Chili Peppers 

In psoriasis, the blood vessel inside the skin’s cutaneous layer becomes dilated. Chili pepper contains capsaicin which makes chili hot. Capsaicin constricts the blood vessels and it also blocks neurological transmission by constricting the nerve endings. Both these mechanisms help to reduce the redness and pain or itching sensation in the affected area.  The use of capsaicin in dermatology is scientifically proven.  Several ointments and creams containing capsaicin are now available in drug stores for treating psoriasis.

Regular meal management & lifestyle measures

• You need to start your day with physical exercise. Both high-intensity aerobic exercise and resistance exercise control free fatty acid synthesis and lipogenesis. Obesity is one of the primary reasons for non-alcoholic fatty liver disease. Daily physical exercise can control obesity and reduce the risk of fatty liver symptoms.
•  Avoid drinking artificial beverages drinking habit during and after the completion of the exercise. You can drink lots of homemade lemon water. Lemon water is the simplest way to get the benefits of lemon. You cut two lemons. Put them into a jug of water, and drink this at a regular interval. The antioxidant property of lemon helps to reduce oxidative damage. Flavonoids present in lemon have a protective effect on the liver.   
• You should drink herbal tea made up of 5gm black seed (kalonji) powder with 5 gm of Lemon Balm leaf (Melissa officinalis) instead of tea and coffee. This is an effective way to reduce non-alcoholic fatty liver symptoms. A randomized clinical trial result reported Thymoquinone is a phytochemical of the black seed that can reduce lipid profile and liver enzyme. Lemon balm also has a hypolipidemic effect. Both of these therapeutic effects are beneficial for a fatty liver condition. You can prepare this herbal tea in your own kitchen. For this, you need to prepare a tea bag with require amount of kalonji and Lemon Balm leaf and store these tea bags in an airtight container. You need to boil 250ml water and put off the flame. Add one tea bag to the boiled water and put the lead wait for 10 minutes and enjoy healthy herbal tea.  
• Turmeric is a common kitchen spice in India and an effective regimen for fatty liver. Raw turmeric rhizome is readily available in vegetable shops. Drinking raw turmeric juice every morning on an empty stomach provides great help to control fatty liver conditions.  A randomized double-blind placebo-controlled human trial showed curcumin, a phytochemical present in turmeric could improve non-alcoholic fatty liver conditions. Different human research studies recommended that 600 mg/ day or 0.6 ml turmeric powder or turmeric oil three times per day is safe and effective to provide medicinal value. Simply, you add raw turmeric juice to fruit juice. Fruit juice masks the pungent taste of turmeric without impacting its benefit.
• Oatmeal is a great alternative to rice and wheat for patients with fatty liver. You can introduce this whole grain to your breakfast and dinner. Oatmeal can reduce body weight. It also limits the risk of diabetes. Both obesity and diabetes are commonly associated with fatty liver. The newspaper Hindustan Times published an article on 28th October 2017 that reported fatty liver was a leading cause of the higher prevalence of diabetes in India.
• If you have an advanced stage of fatty liver with swelling of the liver, then omega-3 fatty acids help to reduce the progression of the condition. The omega-3 fatty acid has an anti-inflammatory effect that reduces liver inflammation. It controls other underlying triggering factors including hypertriglyceridemia. A meta-analysis reported by observing ultrasound diagnosis that omega-3 fatty acid supplements significantly reduce liver fat amount. 
• Include β-carotene, vitamins C, and E-rich food items in the diet. Certain natural food sources are effective against non-alcoholic fatty liver condition. Such as

Walnuts – 30 gm per day

Blackcurrants – 100 g

Parsley leaves – 100gm

Red Capsicum – 100 gm

Horseradish – 100gm

Wheat germ -100gm

Carrot – 100 gm

Dried apricot -100gm

Onion leaves – 100 gm

Mushrooms

Apples

Oranges

Green leafy vegetables

Green tea instead of milk tea or black tea and coffee

Tofu instead of Paneer

Soy milk

Yogurt

Chicken

Fish like Katla, Hisla, Chapila, Morola etc.

Eggs (less than two eggs per week)

Food should be boiled, steamed, or baked without added oil, butter, and ghee as much as possible.

Cooking oil must be extra virgin olive oil.

Meal intake instructions

• Break your overall daily intake into 4–5 meals; give 2 to 3 hourly maximum breaks between meals.
• At least 3 hours gap requires between last meal intake and before sleeping
• Slowly intake your meal and do proper chewing before swallowing
• Finish your eating even before the feeling of satiety, as satiety often feels after 15 minutes of completing eating

4 Inexpensive nutritional supplements

• Turmeric Powder or crushed raw turmeric (1 teaspoon) and a pinch of black pepper powder- mix with hot water. Drink it every morning on an empty stomach.
• Raw garlic –2 bulbs daily with morning meal
• Cod liver oil capsules –twice daily after meal
• Nutrilite Milk Thistle with Dandelion supplement (Amway India) – one tablet twice a day along with your meals

Right exercise habit

At least 30 minutes of daily exercise in the morning hours (between 6 am to 9 am) in sunlight to get natural vitamin D.

Periodic diagnostic tests recommendation

• Liver function tests
• Vitamin D level
• USG (with GP recommendation)

Restrictions for progressive fatty liver

• No alcohol
• No smoking

Follow the above-mentioned regimens for at least three months to get an effective result. But necessarily you need to go for periodic diagnosis to check the progression of the condition.   

The discomfort associated with migraine increases with light and sound effects. Nausea and vomiting are two common symptoms associated with migraine. Migraine is not an age-specific disease. The predominance of the disease is unknown but may occur due to stress, sudden changes in blood circulation or neuro-chemical transport, genetic factors, and hormonal alteration. In 2011, the National Health and Nutrition Examination Survey in the USA reported that 22.7% population had migraine. 

Migraine Cures

Oral administration of the painkillers available in the drug stores can give instant migraine relief. These medications do not provide permanent migraine relief. There is no medication discovered to treat migraine but can only provide temporary pain relief. Besides, people often do not prefer to intake analgesic medicine to avoid side effects. Different natural ingredients are available as home remedies to safely abate the migraine attack. These natural therapies are beneficial to reduce the frequency and severity of attacks. Migraine can also be controlled by regular physical activities that are easy to perform at our home.

Home Remedies for Migraine

Ginger Tea

Ginger is a common kitchen ingredient that usually gives a spicy taste to our food items. Traditionally, ginger has multiple therapeutic benefits that are effective for many clinical conditions like nausea and vomiting. As I mentioned earlier, these two are commonly associated symptoms of migraine. 

Prostaglandin is a pain triggering factor present in the human body through contracting muscle, altering hormonal release, and causing swelling. The presence of two hundred key constituents in ginger oil acts together against the prostaglandin synthesis. Thus, ginger gives relief to the extensive headache that occurs in migraine. Ginger controls stomach upset that worsen the conditions of migraine. Ginger also helps pain relief in migraine along with improving stomach health. Scientific evidence has been proved all these traditional claims through a recent study conducted by researchers from headache clinics in the USA. The research report revealed that ginger supplements could prevent the severity of migraine. Also subsides the associated symptoms like nausea and vomiting. Ginger has blood-thinning properties. Experts suggested not to take ginger pieces directly.

Preparation of ginger tea

Chop the freshly cut 1 ½ inch ginger piece. Add chopped ginger to a pan with 1 cup of water and boil it till the volume become half. After this step, strain the extract and gradually drink the ginger tea by taking a sip.

Mint Leaves

Mint leaf is a chief source of peppermint oil. The typical smell obtained from peppermint oil is due to the presence of menthol, a volatile substance that imparts a cooling effect. Mint leaves are easily available as kitchen items. Mint leaves are usually added to many food preparations for cooling effect during hot summer days. Therapeutically, mint leaves reduce stomach problems like nausea and also relieve spasms. In 2002, the Centers for Disease Control and Prevention (CDC)conducted a National Health Interview Survey. This survey report mentioned that 12 % of migraine suffered patients among 30,000 population used peppermint oil in the USA to get relief from pain. 

Peppermint acts as a stress buster due to its cooling effect. Peppermint also improves the blood flow in the brain by promoting muscle contraction and relaxation of the smooth muscles of the blood vessels. However, more scientific studies are expected to justify this fact. The best result is obtained by applying the peppermint oils locally on the affected site. Inhalation of vapor released from boiled mint leaves also helps to give migraine relief.   

Preparation of topical application

Peppermint oil mixed with eucalyptus oil and ethanol (type of alcohol) gives the best result in migraine relief. For this, crush mint leaves and eucalyptus leaves and take a cotton cloth. Spread both the crushed leaves on the cloth. Add 15 – 20 drops of ethanol and then quickly fold the cloth. Lie on the bed and then cover the forehead with this cotton piece. Close your eyes and take a rest.

If you want a simple solution, buy authentic peppermint oil, and eucalyptus oil to get similar benefits without effort. Ready to use these essential oils are effective relief from migraine.

Drinking of tea or coffee

Drinking tea specifically green tea and chamomile tea have the benefits of relieving migraine. Both these herbal tea are useful for treating the conditions like muscle cramps and stomach spasms linked with irritable bowel syndrome (IBS). Do you know IBS triggers migraine? 

Post-menopausal syndromes also elicit migraine attacks. The condition can be controlled by drinking unsweetened tea. Tea without milk and sweet helps to regulate hormonal changes. Both green tea and coffee contain caffeine. Required quantity of caffeine is useful to get rid of anxiety and also reduces swelling of the blood vessels. But instead of drinking coffee try tea. Too much coffee drinking may create withdrawal syndrome that also includes a headache.  

Cold Compression

Some patients get migraine relief by using ice bags on the forehead during a severe attack. Using Ice bag is an easy way for cold compression. Alternatively, you can also keep some ice cubes inside the folded hand towel if an ice bag is unavailable. Then, you keep the hand towel on your forehead that may constrict blood vessels and reduce the throbbing sensation. 

Some time alternative hot and cold compression is also effective.

The effective stepwise massage technique for migraine  

• Press the muscles of the forehead. First, start from the upper part of the eyebrows and gradually release the pressure.  
• Close your eyes and tightly squeeze the eyelids and generate pressure. Gradually release the pressure and open your eyes evenly.
• Expand your cheek muscles then relax. 
• Tightly grasp your jaw and then rid of the pressure.
• Place your tongue tip at the roof of your oral cavity and generate pressure. Gradually bring the tongue to its original position.
• Join both the lips and hold them tightly. Gradually open them.
• Generate pressure at the backside of the head by pressing against the support (floor, pillow, and chair) and then release the pressure.
• Lift your shoulders up and hold them as much as near to the ears. Then after 30 sec go back to your original posture. Repeat this for a few cycles. 
• Breathing exercises utilizing the diaphragm (dome-shaped elastic rim-like structure present between the chest and abdominal cavity) reduce the frequency of migraine attacks. 

Scientific evidence is not sufficient to support these home-based treatments. But modern medical treatment services recommend some of these as complementary medicines or remedies.

Natural Sinus Relief

Although before the COVID era, we had a practice of using some quick-relief medications for sinus treatment without concerning side effects. But the COVID makes us more health-conscious. Many of us have started traditional natural treatment to avoid common illnesses, especially cold and cough-related conditions. Following are some natural therapy that I recommend for prolonged sinus relief and reducing reoccurrence:  

Water Vapor with Peppermint Oil

Water vapor is a natural mucolytic. Mucolytic helps to liquefy the congested mucous and helps to expel out from the nasal passage. It also helps to have proper moisture balance in the nasal cavity and protect from unnecessary drying. For achieving sinus relief by water vapor, you need to take a bowl full of hot water, peppermint oil, and a clean towel. Keep the hot water bowl on the table and add a few drops of peppermint oil. Peppermint oil contains menthol that synergizes the mucolytic effect of the water vapor. Sit comfortably in front of it. Bend your neck towards the bowl and inhale the water vapor by taking a deep breath. You cover your head during inhalation with a clean towel to prevent the escape of vapor and menthol (volatile that easily gets vaporized) to the surrounding atmosphere. 

Rinsing of Nasal Cavity

The nasal cavity rinsing practice is a debatable process. But studies had been proven that it is very effective for sinus relief. You need to take 1 cup of lukewarm water and mix 1teaspoonful of salt for preparing the rinsing fluid. Stir the liquid until it becomes a solution and let it become cool. Then, stand comfortably in front of a washbasin. Take a small quantity of solution in the palm. Inhale the liquid. Then forcefully exhale to bring out all the congested mucous and other dirt particles that you inhaled during breathing. Initially, it produces discomfort. But the regular practice may become a habituation. 

Topical Application of Garlic- Cinnamon Paste

Garlic is a natural antimicrobial. It has bacteriostatic and bactericidal effects on a varying range of micro-organisms. Cinnamon has an anti-inflammatory property as it helps to release the mucosa and reduces the swelling. Cinnamaldehyde present in cinnamon is a good antibiotic for respiratory infectious agents. Take 4-6 cloves of garlic and one tablespoonful of cinnamon powder to prepare this paste. Make a paste of garlic cloves and add cinnamon powder to it. Locally apply this paste to the affected area (the forehead and nose). This application gradually reduces sinus pain. 

Inhalation of Black Cumin Seed

Black cumin seed has several active constituents that make it a precious natural ingredient for effective relief of all kinds of ailments. The tiny black cumin is effective for sinus relief. Take a clean muslin cloth and add some quantity of black cumin seed. Tie the cloth properly and make a ‘potli’ (a small wrap with thread). Keep this potli with you during winter or when sinus pain occurs frequently. Inhale the smell as much as you can and get rid of sinus problems. 

Mustard Oil Drop

Mustard oil is extracted from mustard seeds. Mustard seeds can break the mucosal congestion by increasing the fluidity of the mucous. It also reduces the pain by blocking the neurotransmission. Mustard seeds can also decrease prostaglandin (pain mediator) production. Moreover, mustard oil also has an antimicrobial property. Take one small cup of mustard oil and add one teaspoonful of mustard seeds and boil it. Then, wait for a few minutes until the preparation cools down. Then, filter the oil and store the mustard oil drop in an air-tight container. Add two drops of mustard oil in each nostril with the help of a dropper. Apply this thrice a day. Otherwise, take some oil in the palm and rub both palms to generate friction between palms. Massage the feet in the same way by using this oil. During the massage, produced heat is a very effective treatment for cold. Add some garlic cloves and black cumin seeds with the oil for a better result. 

Sinus Relief Medication

Hot Lemon Syrup

Lemon is full of vitamin C that increases our immunity against cold. Honey is a good antioxidant and helps to reduce inflammation. These two main ingredients and the other two magical additives make the preparation active against sinusitis. The names of the two other additives are cumin seed and fenugreek seeds. Cumin seeds decrease the production of mucous and reduce the inflammation of the mucous membrane. To prepare this syrup, first, you have to roast cumin seeds and fenugreek seeds with two tablespoonfuls each and then grind them together. Keep this mixture in an air-tight container. Squeeze one lemon juice and add one teaspoonful of honey just before taking the syrup. Slightly heat and add the crushed spices (cumin seed and fenugreek seeds) into it. Individuals who have sinusitis during winter or climate change can administer this syrup with a twice-daily dose for every day. This remedy is helpful to prevent infections and also gives relief from sinusitis. 

The American Institute for Cancer Research and World Cancer Research Fund promoted a plant-based diet. Different plant products can reduce cancer risk. This recommendation is based on the increasing trend of scientific research evidence, which reported fruits and vegetables have health protective effects. [1]The foundation of public health recommends the consumption of diets containing 5 to 10 servings of fruits and vegetables per day are helpful to reduce the rate of cancer prevalence. [2]

Medical advancements offer advanced cancer treatments. But still, conventional medical treatment may not be enough to cure certain types of cancers like lungs, pancreas, liver, bones, and in an advanced stage of breast and colon cancer. Moreover, these conventional therapies are expensive and have various side effects. 

Employing food as medicines in combination with a healthy lifestyle and diet habits are newer approaches to prevent degenerative diseases like cancer.

Orange

Orange is a fibrous, juicy citrus fruit. But do you know this abundant souse of fiber can protect you from cancer? Pectin, a complex carbohydrate present in citrus fruits is the source of polysaccharide fiber. Pectin can disrupt intercellular communication that encourages metastasis and slow down the process. 

Vitamin C and flavonoids combination in orange provide a great antioxidant property. The antioxidant activity of orange juice that is rich in flavonoids prevents oxidative stress in the human lung, diminishes the production of reactive oxygen species (ROS), enhances mitochondrial functionality, and averts oxidative damage of DNA.

Orange juice has anti-inflammatory activity that counteracts cytokine generation and other inflammatory mediator releases. Therefore both antioxidant and anti-inflammatory properties present in orange juice provide desirable benefits against cancerous tumor growth. Not only orange, other citrus fruits like lemon, grapefruit are also good sources of these biochemical compositions. But I am suggesting orange juice as its amazing taste attracts the worldwide population and is even one of the most studied superfoods in terms of its health benefits.

Research scientists had reported that the antiproliferative effect of orange juice is effective against leukemia, breast cancer, and colon tumor. Orange juice can contrary the risk associated with oral and pancreatic cancer. A clinical trial result demonstrated the risk of cancer inversely proportionate with citrus fruit juice like orange juice. [1] An animal study result published in 2020 reported that Orange peel extract and its bioactive compound naringin could be used as an adjuvant therapy with doxorubicin, a chemotherapeutic medicine. The addition of this adjuvant therapy helps to reduce esophageal cancer tumor size and lower down the side effect burden of chemotherapy. [2] Shortly, we expect a clinical trial confirms the efficacy of this non-toxic herbal supplement as an adjuvant for patients undergoing doxorubicin chemotherapy.

Mushroom

Mushrooms have different varieties because of their different genera. Lingzhi or Reishi (Ganoderma), Maitake (Grifolafrondosa,) Lions mane (Hericium erinaceus), puffballs, (Calvatiautriformis), split-gill mushroom (Schizophyllumcommune), winter mushroom (Flammulinavelutipe), birch polypore (Piptoporusbetulinus), and almost all other verities of mushrooms have anticancer property. Anti-tumor, anti-metastasis, and immunomodulating benefits of mushrooms provide cancer-preventive benefits. 

Mushrooms contain a variety of bioactive compounds such as different medicinal polysaccharides like ß-glucans, krestin, and polysaccharide peptide lentinan, etc. However, the composition of mushrooms varies from genus to genus. Multiple research studies have been performed to investigate the antitumoral and immunostimulating effects of mushroom containg polysaccharides. 

Many clinical trials have been performed to check these substances in conjunction with chemotherapy. These trial results indicate relevant health benefits such as overall disease-free survival of colorectal cancer patients and in improving quality of life among lung cancer patients. In Japan and China, different medicinal mushrooms have been approved as adjuvant therapy with standard cancer treatments. The clinical history of patients has reported safe use as a single agent or in combination with chemotherapy. [3]

Mushrooms exert anticancer activity through apoptotic induction, preventing tumor cell proliferation, inhibiting angiogenesis and protein synthesis inside the tumors. Immunomodulatory benefits obtain from mushrooms modulate the immune functioning of our body to act favorably against cancer growth. In the laboratory, researchers found that mushrooms can significantly inhibit the growth of tumor mass. [4]

Medical industries still have a lack of chemotherapeutic treatments for some forms of cancer, like Hodgkin lymphoma, estrogen receptor-negative human breast cancer, acute lymphocytic leukemia, acute myeloid leukemia, mesothelioma, etc. Pharmaceutical companies are searching for new molecules to make up this gap. A plethora of valuable bioactive compounds present in mushrooms attract the pharmaceutical industry. This gives hope of discovery of new cancer treatment. [4]

Mushroom is easily available in the local market. You must include some mushroom preparations in your weekly cooking planner. It is an organic way to supply multiple anticancer bioactive compounds to prepare your body to fight against cancer. 

Broccoli

Broccoli is an example of a cruciferous vegetable. Cruciferous vegetables (broccoli, cabbage, cauliflower) contain sulforophane, which has anti-cancer properties. But remember sulforophane originates in the seed and is not made in the plant. [5] We usually prefer to eat the flower part of the broccoli, which is only 30% of the whole broccoli. If you want to take more amount of sulforophane, then include broccoli sprouts in your diet. However, broccoli leaves and stalks have antioxidant properties. [6] Do not through broccoli leave and stalks during the preparation of broccoli. This suggestion not only saves your money but also safe your health by dispensing extra antioxidants.    

Epidemiologic studies have found that intake of cruciferous vegetables could reduce cancer incidence. According to these study findings, cruciferous vegetable intake could limit cancer progression at the lung, stomach, colon, rectum, bladder, kidney, breast, and prostate. A prostate cancer screening trial found men who consumed more than 1 serving of broccoli per week had a 45% risk reduction of developing aggressive prostate cancer compared to men consuming less than 1 serving of broccoli per month. [7]

Tricolor Recipe of this month

Orange veggies stir fry

Step 1

Prepare sauce by blending orange juice (1/2 cup), grated orange zest (1 tablespoon), big garlic cloves (2 no.), minced ginger (1 teaspoon), rice vinegar (2 tablespoons), soy sauce (2 tablespoons), and a dash of honey. Then, put the blend in the pan and heat for 5 min. Turn off the flame and separate the sauce in a bowl and keep aside.

Step 2

Boil one cup of broccoli for 5 minutes. But it should not get too soft during boiling. Chop one cup of carrot, one cup of mushroom, and half a cup of onion. Take half a cup of fresh peas for this preparation. Then heat a pan. Add one tablespoonful of olive oil. Cook the onion in olive oil and then add all the vegetables into it. Stir fry the veggies for 3 minutes. Add few drops of sauce between each stir. After all the veggies are cooked properly, turn off the flame. Place Orange veggies stir-fry over hot rice. Now you can enjoy the meal. 

References

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491624/
2. https://www.sciencedirect.com/science/article/pii/S0753332219352163
3. https://www.frontiersin.org/articles/10.3389/fphar.2020.580656/full
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339609/
5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC526387/
6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391535/
7. http://www.fda.gov.tw/upload/189/content/2014012817204158505.pdf

On April 29, 2021, the Union Ministry of AYUSH declared that AYUSH 64, “a poly-herbal formulation developed by the Central Council for Research in Ayurvedic Sciences (CCRAS),” could implicitly aid in the treatment of “asymptomatic, mild and moderate COVID-19 infections as an adjunct to standard care”. [1] Many critics have criticized this decision because they doubt the efficacy of AYUSH 64. They believe no reliable scientific evidence supports the benefit of this formulation against COVID-19. [2] NitaNaturale has taken the initiation to jot down all the scientific journals’ published article details to uncover the possible treatment benefits of herbal ingredients present in AYUSH 64 against COVID-19.   

Central Council for Research in Ayurvedic Sciences (CCRAS) in collaboration with the Ministry of AYUSH, Govt. of India has launched a poly-herbal formulation, AYUSH–64 to treat malaria. In 1980, CCRAS has also patented this through National Research Development Corporation after evaluating the safety and efficacy of AYUSH–64 (Patent number 152863). [3, 4] 

Clinical Trial details of AYUSH-64

Two human trials had performed to check the efficacy of AYUSH–64 as an anti-malarial drug. Initially, a generalized clinical trial designed had been made to evaluate the anti-malarial efficacy of AYUSH 64. In this study, 1442 positive malaria cases were enrolled at different research institutes and the Center of The Council located in different regions of India. The obtained study result found 89% treatment response that is comparable with Chloroquine and Primaquine (two most commonly used anti-malarial drugs). Later, a double-blind clinical trial was conducted on 178 malaria patients. The study result reported 95.4% drug efficacy. Both of these study findings reported no side effect or toxicity history with the prescribed dose. AYUSH–64 specifically acts against Plasmodium vivax and less efficaciously against Plasmodium falciparum.  Plasmodium vivax and Plasmodium falciparum are two common human malaria parasites. [3]

However, another animal research result observed that AYUSH–64 not efficacious against P. berghei, P. yoelii nigeriensis, P. cynomolgi B, and P. knowlesi, four other malaria parasites. [5]

A pilot study had conducted between June 2018 and July 2019 at Raja Ramdeo Anandilal Podar Central Ayurveda Research Institute for Cancer, Mumbai for CCRAS. This trial aimed to evaluate the safety and efficacy of AYUSH 64 in clinically diagnosed Influenza-like illness (ILI). The study author concluded that AYUSH 64 along with standard care was safe and effective against ILI. This formulation also speeds up recovery. Researchers of this study also expected that this poly-herbal formulation might act as an adjuvant therapy with standard care for treating other viral infections that increase body temperature (fever). [6]

Benefits of each of the herbal ingredient present in AYUSH- 64

Composition

Each AYUSH- 64 tablet contains

• Saptaparna(Alstonia scholaris  Br.) bark aqueous extract 100 mg
• Katuki(Picrorhiza kurroa Royle ex. Benth) root extract 100 mg
• Kiratatikta (Swertia chirata  Karst) whole-plant extract 100 mg
• Kuberaksha(Caesalpinia crista ) seed powder 200 mg

Dose as an antimalarial drug

• Adults need to take 4 tablets (500 mg per tablet) thrice a day for 5 to 7 days
• Children should take 2 tablets thrice a day for 5 to 7 days [3]

Saptaparna Bark

The botanical name of saptaparna or ‘devil’s tree’ is Alstonia scholaris. Cutting off this plant bark releases milky latex. Traditionally the bark of this tree was used for treating malaria fever. The bark extract is also useful as an antiplasmodial, immune-stimulant, hepatoprotective, and anticancer agent. In Ayurveda, the overnight soaked bark of this plant uses to control blood sugar levels.  [7]

Based on these traditional uses, many scientific research studies had performed. Most of the study findings reported positive results of these traditional therapeutic applications. Researchers found Saptaparna plant containing alkaloids were also effective against broncho-constriction and an effective anti-tussive remedy. [7] Evidence also supports that Saptaparna bark has antimicrobial property. [8]

Herbal researchers reported that the oral dose limit of this bark extract is 2 000 mg/kg body weight. Therefore, administration within this dose limit does not cause any side effects. [9]

Source: https://www.researchgate.net/publication/287720380_A_phytopharmacological_review_of_Alstonia_scholaris_A_panoramic_herbal_medicine

Katuki root extract

Picroside I and Picroside II, cucurbitacins, and phenolic components of Katuki root extract cure numerous illnesses such as fever, liver problems, spleen disorder, and asthma. [10] 

Source: https://www.researchgate.net/publication/318984001_A_REVIEW_ON_MEDICINALLY_IMPORTANT_SPECIES_OF_PICRORHIZA_A_REVIEW_ON_MEDICINALLY_IMPORTANT_SPECIES_OF_PICRORHIZA

It has been found that Katuki root extract inhibits allergen and platelet-activating factor (PAF)-induced bronchodilator. Thus, this herbal ingredient is effective in reducing the severity and frequency of asthma. This herb also can lower blood sugar levels. Apocynin is a phytochemical present in Katuki root extract. This phytochemical inhibits thromboxane A2 production to control inflammatory pathways to prevent inflammation. [11]

Kiratatikta whole-plant extract

Different Ayurveda formulations such as AYUSH 64, Diabecon, Mensturyl syrup, and Melicon V ointment contain this herbal ingredient. This medicinal plant has antipyretic, hypoglycaemic, antifungal, and antibacterial properties. Traditionally, a decoction of this herb is used for different therapeutic purposes due to its antimalarial, antifatigue, anti-inflammatory, anthelmintic, antifungal, antibacterial, antidiarrheal, anti-aging, cardio-stimulant, cardio-protectant, hepato-protective, hypoglycemic, and blood pressure, and blood sugar-lowering effects. Several scientific research studies have also evaluated the medicinal properties of Kiratatikta plant extract. No significant side effects were observed in any of the researches. [12]

Swertia chirayita. (A) Seeds, (B) Plant in nature, (C) Root of a mature plant, (D) Dry plant material, (E) High shoot multiplication in a plant tissue culture system.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709473/

Kuberaksha seed powder

Caesalpinia crista Linn. (C. crista), is the botanical name of this plant. This plant is commonly known as Fever nut. The led-colored, oblong-shaped seeds of this plant are 1.3 cm long. One or two seeds are present in one pod. Kuberaksha seed kernels are traditionally used to treat intermittent fever, asthma, and colic. An animal research study showed the antipyretic property of Kuberaksha seed powder and the effect is comparable with paracetamol. An in-vitro study conducted in Indonesia and Myanmar reported that diterpenes present in Kuberaksha have anti-malarial efficacy. [13] Kuberaksha seed powder also has adaptogenic properties, along with antibacterial, antifungal, and antiviral effects. In addition to these, multiple scientific research studies reported that the Kuberaksha seed has anti-diabetic, cardio-protective, and antioxidant properties. [14]

                 Kuberaksha seed

Source: https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/caesalpinia

How composition of AYUSH 64 effective against COVID-19?

Fever is the most common symptom of COVID-19. [15] Clinicians reported that the fever, dry cough, dyspnea, and fatigue associated with COVID-19 could turn to pneumonia and acute respiratory distress syndrome in severely affected patients. Advanced age, ischemic and congestive heart disease, hypertension, diabetes, and chronic obstructive pulmonary disease (COPD) are the most significant causes of COVID-19 associated death. [16] Asthma patients have a higher risk to develop severe COVID-19 symptoms. [17]

The poly-herbal composition of AYUSH 64 is effective in the treatment against fever. Different scientific researchers concluded from their research works that every ingredient of this formulation got antipyretic properties. Medical researchers have expected that anti-PAF activity could inhibit the activation of human mast cells that largely present in the lungs. These mast cells may have a contribution to COVID-19 severity. Mast cells induce inflammatory mediators release that increases the risk of the severe acute respiratory syndrome (SARS) associated with COVID-19. Researchers also assumed that anti-PAF activity along with anti-inflammatory action of some natural ingredients could act as a prophylactic treatment against COVID-19. [18] It has already been mentioned that AYUSH 64 containing Katuki root extract inhibits PAF and induces bronchodilation. Kiratatikta whole-plant extract of this formulation also has significant anti-inflammatory properties. These herbal ingredients may also reduce post-Covid complications like increased blood pressure, blood sugar, anxiety, and different metabolic disorders.

Research evidence

• A research study showed that human coronaviruses (HCoVs) are commonly associated with ILI [19], though HCoVs have different strains. A pilot trial result found that administration of AYUSH 64 with standard care could decline ILI symptoms with a faster recovery rate than those only in standard care. This early recovery may happen because herbal ingredients present in AYUSH 64 help to restore metabolism and strengthen the immune status. This trial result also found that AYUSH 64 is a well-tolerated preparation. [6]
• Another ongoing randomized trial is also going on under CSIR to evaluate the efficacy of AYUSH 64 as an adjunct treatment to standard of care. [20] We hope soon this study will be completed and the test result will be declared.

Indication

Experts suggest that the AYUSH- 64 is effective against mild to moderate COVID-19 cases with initial symptoms like fever, cough, malaise, headache, body ache, nasal congestion, nasal discharge, etc. Asymptomatic COVID-19 patients who have confirmed their disease through RT-PCR can preferably start AYUSH- 64 within 7 days of diagnosis of the condition. [21]

Dose

Two tablets of 500 mg twice daily are recommended for prophylactic treatment.

Experts suggest that AYUSH-64 be continued for a minimum of 14 days. However, if required, one can take this medicine up to 12 weeks based on the advice from a qualified AYUSH practitioner. Pregnant and lactating mothers should not take this formulation as yet now no studies are performed on them. [21]

NitaNaturale does not claim that AYUSH-64 is an effective treatment for COVID-19. But this blog can help readers to unfold the therapeutic benefits of each herbal ingredient present in AYUSH-64.

References

1. https://www.pib.gov.in/PressReleasePage.aspx?PRID=1714815
2. https://science.thewire.in/the-sciences/what-message-does-the-government-promoting-ayush-64-today-send/
3. http://www.ccras.nic.in/sites/default/files/II%20Ayurveda%20Day/English/Ayush%2064.pdf
4. http://www.ccras.nic.in/sites/default/files/viewpdf/Patent%20Granted.pdf
5. https://pubmed.ncbi.nlm.nih.gov/1824361/
6. https://www.sciencedirect.com/science/article/pii/S0975947620300255
7. https://www.researchgate.net/publication/287720380_A_phytopharmacological_review_of_Alstonia_scholaris_A_panoramic_herbal_medicine
8. https://ijpsr.com/bft-article/phyto-pharmacognostical-evaluation-and-hptlc-finger-printing-profile-of-leaves-of-saptaparna-alstonia-scholaris-l-r-br/?view=fulltext
9. https://link.springer.com/article/10.1007/s11655-011-0947-0
10. https://www.sciencedirect.com/science/article/abs/pii/S2210803320300300
11. https://www.researchgate.net/publication/318984001_A_REVIEW_ON_MEDICINALLY_IMPORTANT_SPECIES_OF_PICRORHIZA_A_REVIEW_ON_MEDICINALLY_IMPORTANT_SPECIES_OF_PICRORHIZA
12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709473/
13. http://globalscitechocean.com/ReportFile/46dd0a364a3a4b42acdb2b8e82e6b5c8.pdf
14. https://www.researchgate.net/publication/313678924_Pharmacology_and_medicinal_properties_of_Caesalpinia_crista_-_An_overview
15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544962/
16. https://aacijournal.biomedcentral.com/articles/10.1186/s13223-020-00509-y
17. https://erj.ersjournals.com/content/early/2020/10/22/13993003.03142-2020
18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430296/
19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703274/
20. https://iiim.res.in/cured/ayush.php
21. https://www.ayush.gov.in/docs/Ayush123.pdf

Evidential background for the recommendation

A mixture of Black seed and honey has the potential benefits to prevent as well as reduce the severity of Coronavirus infection. The Hindu ePaper published an article on their BusinessLine Page On 9th November 2020. The report mentioned that a multicentre randomized, controlled clinical trial showed a combination of 1 gm/kg/day of honey and 80 mg/kg/day of Black seed (scientifically known as Nigella sativa) treatment for 13 days was effective to clear viral load and alleviated symptoms of Coronavirus infection. This study result found that anti-diabetic, anti-hypertensive, cardio-protective, and broncho-dilatory properties of honey and the Black seed mixture could reduce the mortality rate among high-risk patients who had diabetes, hypertension, cardiac disorders, or asthma. [2] Based on this promising study result, Intas Pharmaceuticals Limited has recently launched its new patented tablet formulation, Thymotas. Thymoquinone and honey are the two primary ingredients present in Thymotas formulation.[3] Your Black seed is a rich source of Thymoquinone.

Why we have to depend on black seed and honey mixture or such natural remedies to deal with the Coronavirus pandemic?

Research and development departments of different Pharma companies are working hard to speed up to launch of vaccines as well as specialized treatment for COVID-19 infection as early as possible. But no licensed vaccine or specific treatment for coronavirus infection till now available in the market. In such conditions, nature offers a new remedy. A mixture of Black seed and honey to strengthen our immune system to fight against Coronavirus infection.

How a combination of black seed and honey is effective against Coronavirus infection?

Both Black seed and honey are common traditional remedies used in different airway disorders such as throat infections, bronchitis, flu, and pneumonia. [4,5] Moreover, Black seed oil is a useful treatment for chronic pain symptoms such as headache and back pain, etc. Therefore, these traditional applications indicate these two natural ingredients have the potential to use in COVID-19 infection. The scientific explanation is a little detailed. But this detailed explanation helps readers to understand why this combination they should include in their regular regimen during this pandemic.

The combination of bioactive phytochemicals presents in black seeds and the unique nutritional composition of honey not only an effective remedy to boost immunity for preventing Coronavirus infection but also has the potential to reduce the risk of severity of the symptoms of Coronavirus infected patients. Research experts recommended black seed containing Thymoquinone in combination with honey can be used as an adjuvant therapy with conventional standard prescribed treatment to obtain better therapeutic outcomes against Coronavirus infection. [3]

Thymoquinone is the chief bioactive phytochemicals present in Black seeds. Along with Thymoquinone, thymohydroquinone, thymol, dithymoquinone, carvacrol, and β-Pinene present in the Black seed are worked together and exert antioxidant, antimicrobial, anti-diabetic, antihypertensive, and reno-protective effects. All these therapeutic benefits are essential treatment approaches for Coronavirus infected patients. [5] Whereas, the flavonoids and polyphenolic compounds present in honey may impart antimicrobial, antiviral, and antioxidant effects. [6]

Medicinal Property	Mechanism of Action	Research Evidence
Boosts immunity and reduces viral load	Black seed increases CD4 count and production of interferon- (INF-) gamma with and also activates T cell functioning. [5] Honey has attributed antiviral effect due to its osmotic effect, naturally low pH, and presence of bioactive natural compounds. [4] Flavonoids and its other derivatives present in honey exert a broad-spectrum antiviral effect. [4] Honey targets the 3‐chymotrypsin‐like cysteine protease enzyme of SARS‐CoV, which is one of the most promising targets for drug discovery against coronaviruses. [4]	The clinical trial result reported Black seed is effective against hepatitis C virus. Treatment with Black cumin seed oil exerts symptomatic relief and improves laboratory parameters. [5] The antiviral effect of Black seed is effective against multiple viral infections, such as murine cytomegalo virus infection, avian influenza (H9N2), Chistosoma Mansoni Infection, PPR virus, Broad bean mosaic virus, HIV, Hepatitis C Virus, Zucchini Yellow Mosaic Virus, and Papaya Ring Spot Virus. [7] Honey inhibits the viral replication of the influenza virus due to its virucidal effects. It synergistically interacted with the other antiviral medicines. [4]  Apart from the influenza virus, honey is also effective against human respiratory syncytial, human rhinovirus, human metapneumovirus, parainfluenza, and betacoronavirus. [4] Although the antiviral effect of honey against the novel coronavirus (SARS‐CoV‐2) has not been confirmed yet, [4] but a combination of honey and Black seed is effective to prevent and reduce the severity of coronavirus. [2] The combination of Black seed and honey is also offered protection against HIV transmission from pregnant women to the fetus. [5] Recently, a trial result confirmed that a combination of Black seed and honey is also offering protection and reduce the severity of COVID-19. [2]
Bronchodilator	Thymoquinone‚ the main component of Black seed reduces tracheal contraction, and anti-inflammatory effect reduces bronchial inflammation. The antispasmodic effect relaxes the smooth muscles present in the airways. [5] Honey is a natural demulcent that soothes cough symptoms. It increases cytokine release and provides apparent benefit in the common cold. [9]	A preclinical research result supported that Black Seed has a preventive effect against pulmonary fibrosis and inflammation. [8]   A clinical trial result concluded that honey is a cost-effective cough treatment. [9]
Antioxidant property	Black seed consumption increases antioxidant enzymes like erythrocyte glutathione peroxidase and superoxide dismutase activity and also reduces free radicals (plasma malondialdehyde).  [5]   Phenolic and flavonoid components of honey responsible for the antioxidant property.  [6]	A human trial result reported that consumption of Black seed oil for eight weeks significantly diminishes the superoxide dismutase free radical (SOD) level. [5] The strong antioxidant property of honey improves the nutrition quality and provides positive benefits for human health. [6]
Antidiabetic property	Black seed intake improves the pancreatic β-cells degeneration, reduces pancreatic inflammation, and congestion. [5]   Honey containing oligosaccharides as well as Palatinose-based balanced formula improve glycaemic response in diabetic patients.  [10]	A human trial result reported that administration of black seed oil with a dose of 3ml per day for 20 days showed a marked reduction of random blood sugar and glycated hemoglobin A1c levels. [5]   Multiple clinical studies showed positive antidiabetic outcomes with honey supplementation.  [10]
Antihypertensive	Black seed and its active component, thymoquinone can act as a calcium channel blocker and increase urine output due to its potent antioxidant property. [5]   The antioxidant property of Honey regulates oxidative stress and effective to control blood pressure.  [11]	A human trial result showed that Black Seed oil significantly lowers systolic, diastolic, and mean arterial blood pressure along with heart rate, total cholesterol, and low-density lipoprotein cholesterol level. [5]   Honey supplementation reduces elevated systolic blood pressure levels. [11]
Reno-protective	Antioxidant, anti-inflammatory, and antitoxic properties of Black seed and its phytochemical thymoquinone help to maintain kidney function. [12] Better management of oxidative stress by supplementation with honey gives kidney protection.  [11]	The pre-clinical trial result showed a positive benefit of Black seed on kidney tissue.  [12] Pre-clinical research showed the positive benefits of honey supplementation. [11]

I hope you can understand now why NitaNaturale recommends you to add a combination of black seeds and honey. The antiviral, broncho-dilatory property, broad-spectrum antioxidant property, and regulating or boosting immune functioning. Along with improving the possible comorbid conditions like regulating blood sugar, pressure, and kidney functioning of the combination of black seeds and honey indicate that we can use this combination as a self-care treatment against SARS-CoV-2. [3]

Tips to use Black seed and honey

• I hope you use the whole Black seed in your kitchen. Whole Black seed is a common flavoring spice often used for seasoning purposes. Whole Black seed is completely safe and does not have any side effects. According to the different research studies, I have found that Black seed oil has optimal therapeutic benefits in comparison with Black seed powder. Therefore, it is better to intake Black seed oil than the whole black seed to gain therapeutic benefits. But NitaNaturale will give additional tips for those who use the whole Black seed as a kitchen ingredient and do not want to spend extra to buy Black seed oil.
• Take a teaspoon of Black seed and ground them freshly. Add the powder into a small cup of boiling water. Close the lid and wait for a minute. Then put off the flame. After 7 to 10 minutes, add one teaspoon of honey and enjoy the warm drink every morning.  This small lifestyle change may give you protection not only from Covid-19 but helps to prevent other microbial infections, normalize blood glucose, cholesterol, and can also regulate blood pressure.
• I have committed to explaining all the science behind the tips given in the NitaNaturale. Therefore, I just wanted to add that instead of using Black seed oil, fresh Black seed powder has enough efficacy to fight against Covid-19. I found during my research that a human trial result confirmed that boiled extract of Black seed had a potent bronchodilatory effect. [13] Another research also confirmed that ground black seed has an antimicrobial effect.  [14] Even Black seed powder provides better plasma lipid control. [15]
• Select Arabian origin-based organic Black seed, which is better compared to other origins in respect of therapeutic value. [16] Another important tip is to use Manuka honey, which has better therapeutic benefits than other varieties. [17]

What precautionary measures essential to know about Black seed and honey?

If any individual has an allergic tendency towards Bee products, then honey may not be a suitable option for them. During pregnancy, Black seed intake is not recommended as it can delay uterine contraction. Individuals who are under blood clotting medications should not take Black seed without consulting with the doctor. [18]

References

1. https://covid19.who.int/
2. https://www.thehindubusinessline.com/news/variety/honey-and-nigella-sativa-help-in-covid-19-viral-clearance-and-reduce-severity-study/article33056708.ece
3. https://indiadailymail.com/technology/intas-launches-thymotas-as-adjunct-to-covid-treatment-business-journal/
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536959/
5. https://www.hindawi.com/journals/ecam/2019/1528635/
6. https://www.ejmo.org/pdf/IN%20Silico%20Approach%20of%20Some%20Selected%20Honey%20Constituents%20as%20SARSCoV2%20Main%20Protease%20COVID19%20Inhibitors-36102.pdf
7. https://pharmacologyonline.silae.it/files/newsletter/2019/vol2/PhOL_2019_2_NL007_Molla.pdf
8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987441/
9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264806/
10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909917/
11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270456/
12. https://www.karger.com/Article/Fulltext/486829
13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387228/
14. https://pubmed.ncbi.nlm.nih.gov/22238497/
15. https://pubmed.ncbi.nlm.nih.gov/26875640/
16. https://pubmed.ncbi.nlm.nih.gov/22238497/
17. https://www.intechopen.com/books/honey-analysis-new-advances-and-challenges/health-benefits-of-honey
18. https://www.healthline.com/nutrition/kalonji-nigella-seeds#TOC_TITLE_HDR_11

What is diabetes? 

Diabetes is an abnormal health condition and indicative of a high blood sugar level. Broadly, diabetes is two types- type I and type II. Type – I diabetes occurs due to an immune system attack that damages the pancreatic cell and causes insufficient insulin production.

Type II diabetes is the condition in which the body unable to utilize or produce insulin. However, type II diabetes is not an auto-immune condition. Diabetes can occur at any age.

Apart from these two types, gestational diabetes is common among pregnant women, but after childbirth the disorder usually self-corrected. [2]

Diabetes become a global health concern

Administration of insulin is the primary treatment for type -I diabetes, whereas different conventional hypoglycemic medications prescribe to control type II diabetes. The uncontrolled diabetic condition leads to a variety of health complications, such as foot problems, nerve damage, heart disease, kidney failure, stroke attack, eye disorders, dental problems, etc. The incidence rate of diabetes increases day by day. It is assumed that worldwide 380 million people will be affected by diabetes by 2025. [3] This increasing incidence and diabetes-associated vital organ disorders make this a global health issue.

What are the Herbs and Superfood act as adjuvant therapy in diabetes management? 

Obesity and dyslipidemia are common in type II diabetes and underlying causes of many complications. Following are some herbs and Superfood complement the blood-glucose-lowering effect of hypoglycemic medicines and also control the underlying complications. But I never suggest these can be used as a substitute for conventional diabetic treatment and stop using prescribed medicine without consultation with a doctor.

Cinnamon

The sweet aroma of cinnamon bark is not only a food flavoring spice but can improve glucose utilization in our body and increase insulin secretion. Cinnamon provides an ‘insulin-like’ effect. The bioactive ingredients present in cinnamon able to lower blood sugar level by following way:

• increase cellular utilization of glucose (a type of sugar)
• converts more glucose to glycogen and stored them for future utilization
• reduce the conversion of glycogen to glucose by decreasing the activity of glycogen synthase kinase 3β
• Increases the activity of glucosidase enzymes and thus reduces intestinal absorption of glucose
• regulate the energy level by controlling intestinal enzymatic activity. [4]

Cinnamon can lower blood cholesterol through reducing triglyceride, total cholesterol, and LDL (bad) cholesterol levels, whereas it increases HDL (good) cholesterol levels in the blood.

• Cinnamon inhibits hepatic HMG Co-A reductase enzyme and reduces blood cholesterol level
• The antioxidant effect of cinnamon reduces lipid peroxidation and inhibits 5-lipoxygenase enzyme activity in the liver and provides a cholesterol-lowering effect.
• Cinnamon also has lipolytic activity and also promotes phagocytosis (engulf) of LDL cholesterol. [5]

Research result also suggested that cinnamon might effective to manage blood glucose level in pre-diabetic people. [6] If your blood test report showed glucose level is borderline, then I recommend you to add cinnamon in your daily diet as a preventive measure.

The selection of dose is critical and usually depends upon patient conditions like a diagnostic report, body weight, current medication, etc. However, I referred to different clinical studies and found 1 gm of cinnamon powder per day can control blood sugar in diabetic patients within three months. [5] But do not increase intake of cinnamon 6 gm per day to avoid any unpleasant side effects like liver toxicity. [7]

Tips to include cinnamon bark in your daily diet for better diabetes management 

You can add a measured amount of cinnamon powder in oatmeal and muesli as a flavoring agent and also for better diabetes management. Cinnamon aroma enhances the flavor of different sweet confectionery recipes. But if you want to grasp its bioactive property to get optimum health benefits of cinnamon then prepare herbal tea by adding three inches of cinnamon bark in a cup of hot water and close the lid for 10 minutes and enjoy the drink. Cinnamon has a long shelf-life and easily store for 4 to 5 years in an air-tight container. Another useful tip that I want to share with readers is to select the Ceylon variety of cinnamon to get the best treatment outcome.

Fenugreek

I recommend fenugreek seed solution for newly detected diabetic patients to control their glycemia and dyslipidemia conditions.

• Fenugreek contains soluble fibers such as glucomannan fiber restrict sugar absorption in your gut.
• Fenugrecin and trigonelline are two alkaloids present in fenugreek have hypoglycemic effects
• Fenugreek stimulates the pancreas to release insulin due to an amino acid (4 hydroxyisoleucine) present in this herbal ingredient. [8]

Tips to include fenugreek seeds in your daily diet for better diabetes management 

Take 25 mg of fenugreek seeds and add them into a glass of water. Keep it overnight for soaking and drink the solution next morning in an empty stomach. Continue this therapy for one month. But monitor your blood glucose level regularly and maintain a dairy to keep the record of your blood sugar level. A human trial result reported that fenugreek seed solution significantly reduced overall cholesterol levels. [9]

Blueberry

Blueberry is a perfect Superfood for diabetic diet due to the following reasons:

• Blueberry has a low glycemic index and.
• Normalize blood sugar level by reducing insulin resistant
• It also acts against obesity and metabolic disorders. [10]

Tips to include blueberry fruits in your daily diet for better diabetes management 

Patients with type II diabetes can maintain their blood sugar level within a normal limit by adding blueberry in their daily diet. A bowl of blueberry can be a diabetic snake item. You can also mix Acai berries, Cranberries in your Blueberry bowl to make it a colorful and antioxidant-rich diabetic healthy diet to support the vital functioning of your body.

Moringa 

Moringa becomes a more discussed Superfoods nowadays due to its multiple health benefits. One of the significant benefits of this herb is blood glucose maintenance within a normal limit. The glucose tolerance test has proven this benefit of moringa. The phytonutrients present in this Superfood effectively reduce post-prandial hyperglycemia and hemoglobin A1C (HbA1C) levels. Moringa exerts an antihyperglycemic effect due to the following reasons:

• Delays the intestinal glucose absorption
• Increases glucose uptake in skeletal muscles and reduces glucose production in the liver by regulating enzymatic activity. [11]

Tips to include Moringa in your daily diet for better diabetes management 

Leaves, seeds, and pods of Moringa have antidiabetic properties. You can add moringa leaves, and fruits in your soup preparation. Moringa powder is available in different organic shops, but you should keep your eyes on the authenticity of the product to avoid any adulteration. You add 500mg moringa powder in green smoothie preparation and drink this healthful appetizer any time a day. But you should monitor blood sugar levels every day to avoid hypoglycemia.

Role of modified lifestyle measures in diabetes management  

Physical activity has a positive role in diabetes management. Brisk walking, aerobic exercise, and swimming are different physical activities diabetic patients can include in their daily life to maintain blood glucose levels. But I recommend yoga should be an integral modified lifestyle measure for the diabetic patient for better management of overall health condition.

The systematic approach of yoga is not only limited to physical health but also influence mental well-being. Yoga can advocate mind-full eating and stress-free life, which are two essential parameters to prevent raising blood glucose levels. [12] The following are significant benefits of yoga in diabetes management:

• Yoga can regulate eating patterns
• Practicing yoga support mind-body connection, which improves self-awareness
• Yoga brings modest weight loss
• Regular yoga practice can significantly reduce both fasting and post-prandial blood sugar. [13]
• Yoga is also an effective diabetes preventive measure.

 How to practice yoga for diabetes management?

I have researched and found the following yoga schedule that can lower down both fasting and post-prandial blood sugar. But you have to follow this schedule regularly. You can observe a noticeable change in the blood test report and health parameters within six months.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437062/

My aim to include this topic in my blog is to increase general awareness. Not only depend on polypharmacy to control blood glucose labels but bring changes in daily life after reading this blog and help the world to fight against the increasing incidence of diabetes and its complications.

References

1. https://www.sciencedirect.com/science/article/abs/pii/S175646461930218X
2. https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358966/
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220230/
5. https://care.diabetesjournals.org/content/26/12/3215
6. https://www.sciencedaily.com/releases/2020/07/200721102143.htm
7. https://www.hindawi.com/journals/ijfs/2019/4138534/
8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954247/
9. https://www.hindawi.com/journals/jdr/2019/8507453/
10. https://www.foodandnutritionjournal.org/volume6number3/superfoodsrecent-data-on-their-rolein-the-prevention-of-diseases/
11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950081/
12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145966/
13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437062/