Diseases Preventing – Nita Naturale

Aloe vera gel benefits

Nita — Mon, 25 Apr 2022 11:54:38 +0000

Aloe vera has a long history of medicinal applications to treat multiple topical and internal disorders. According to Egyptian history, Aloe vera was one of the key secret ingredients of Cleopatra’s beauty regimen. John Goodyew recorded the benefits of Aloe vera in The Dioscorides’ Medical treatise De Materia Medica in A.D. 1655. Americans started using Aloe vera as a laxative by the time of early 1800. But the skin benefit of this herb was evidentially noticed during the mid-1930s as a treatment for radiation dermatitis. Aloe vera has the potential to cure many chronic conditions also. [1] Aloe vera is an extensively used natural ingredient in cosmeceuticals for wound healing and other skin conditions. [2]

Acne

Aloe vera has an anti-acne effect and is clinically used to treat acne vulgaris. [1] The application of aloe vera clears acne and associated spot marks. Clinical experts recommend aloe vera also to other skin problems like skin allergy, spot marks, and skin blemishes treatment to get clearer skin. [3]

Sunburn

The mucilaginous gel obtained from Aloe vera leaves is an effective treatment for sunburn. The effectiveness of Aloe vera gel has evidentially proven to cure sunburn. [4] Aloe vera gel application can reduce burning sensation and inflammation, relieve pain, and speed up wound healing at the skin burn. Aloe vera gel is an effective remedy for sunburn and effective in mild burn treatment. [3]

Moisturizer

Moisturizer is an integral part of our regular skincare regimen. Aloe vera improves skin hydration and is considered an excellent skin Moisturizer. [3] A human trial result found that aloe vera topically applied for two weeks could increase the moisture content of the outer layer (stratum corneum) of the skin surface. Experts recommend that individuals with dry skin can also apply freeze-dried Aloe vera extract for better results. [5]

Anti-aging

Skin wrinkle is a prominent symptom of skin aging and occurs due to loss of skin hydration. Aloe vera helps to retain moisture content on the skin layers. Aloe vera containing different anti-wrinkle skin creams is available on the market. [3] This herb also effectively alters the collagen content by increasing collagen production to hold skin integrity.[6] Altogether these mechanisms can prevent skin aging and associated symptoms.

Wound healing

Aloe vera works excellently in wound healing. Aloe vera promotes wound healing by following three mechanisms of action. Aloe vera acts as an inhibitor of thromboxane. The release of thromboxane delays the wound healing process. Aloe vera also accelerates the wound healing process and reduces inflammation due to its anti-inflammatory effect. This herb inhibits inflammatory mediators like interleukins release and reduces TNF alpha levels and leukocyte adhesion. Aloe vera contains magnesium lactate, which blocks histamine production to stop itching and skin irritation. Aloe vera promotes cytokines synthesis and boosts immunity. [6]

Skin disorders

Aloe vera juice and extract are effective for psoriasis, eczema, seborrheic dermatitis, and wart treatment. Many dermatologists prescribe Aloe vera containing cosmeceuticals to reduce skin rash pads. [3] Aloe vera has antiseptic, antibacterial, and antifungal properties. The antifungal property of Aloe vera is effective against Candida albicans. The antibacterial properties of Aloe vera are also effective against many bacteria, such as Pseudomonas aeruginosa, Streptococcus pyogenes, and Streptococcus faecalis. [7]

Hair health

Both antibacterial and antifungal properties of aloe vera prevent dandruff growth on the scalp. Fungal infection-induced alopecia can also be treatable with the aloe vera plant. [2] Aloe vera gel is also recommended for hair loss treatment. Traditionally, scalp massage with Aloe vera juice mixture with wheat germ oil and coconut milk helps hair re-growth. [3]

Genital disorders

Aloe vera fresh juice is a home remedy for vaginal infections. A human trial result also reported that male genital herpes might be effectively treated with Aloe vera containing hydrophilic cream. [3]

Antiviral effect

Aloe vera has antiviral properties which effectively kill different viruses, such as Herpes simplex virus type 1 and type 2, Varicella zoster virus, pseudorabies virus, and influenza virus. Anthraquinones present in aloe vera leaves, rook, and bark have virucidal activity against both DNA- and RNA-containing enveloped viruses. [7]

Aloe vera also protects our internal organs by increasing white blood cells or macrophages and T cells to modulate immunity. It has potent antioxidant properties because vitamins A, C and E are present in this herb that neutralizes free radicals. Thus it reduces the progression of cancer. [7] Aloe vera juice ingestion often controls blood sugar in diabetic patients. [3] Anthraquinones in Aloe vera gel regulates intestinal peristalsis movement and act as a laxative by increasing intestinal water content that treats constipation. [7] Experts also recommended Aloe vera because of multiple therapeutic potentials like anti-tumor, anticancer, and HIV treatment activities. Heart health benefits can also obtain with Aloe vera juice intake. This herbal remedy can control blood pressure, the accumulation of fats in the blood vessels that prevents blood coagulation within the blood vessels. Thus, Aloe vera normalizes blood circulation within the heart and other organ systems.[3] However, all these benefits are not clinically proven. Different search engines, databases, and trial registries provide these data. [6]

Contraindication

Individuals with aloin hypersensitivity history or who tend to have an allergic reaction should avoid Aloe vera. Aloin is a type of anthraquinone. Pregnant women and lactating mothers should not take Aloe vera, though no evidential genotoxic effect has been proven. [4]

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763764/
https://www.hindawi.com/journals/bmri/2015/714216/
http://www.jocpr.com/articles/aloe-vera–a-potential-herb-and-its-medicinal-importance.pdf
https://www.naturalmedicinejournal.com/journal/2012-09/aloe-vera-gel-research-review
https://pubmed.ncbi.nlm.nih.gov/17026654/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330525/
https://www.hindawi.com/journals/jds/2014/210463/

Does AYUSH 64, an established anti-malarial poly-herbal formulation effective against COVID-19?

Nita — Sat, 15 May 2021 12:13:34 +0000

Nobody can ignore the fearful situation that has arrived due to the COVID-19 pandemic. Multiple pharmaceutical products are already marketed and some are in pipeline expecting to give us relief from this life-threatening disease. During this pandemic, not only allopathic medicines, but researchers are working in alternative and complementary medicinal systems to find out an effective solution against this deadly virus. People also started taking different traditional medicinal herbal remedies to boost their immunity to get a victory against the COVID-19 attack.

On April 29, 2021, the Union Ministry of AYUSH declared that AYUSH 64, “a poly-herbal formulation developed by the Central Council for Research in Ayurvedic Sciences (CCRAS),” could implicitly aid in the treatment of “asymptomatic, mild and moderate COVID-19 infections as an adjunct to standard care”. [1] Many critics have criticized this decision because they doubt the efficacy of AYUSH 64. They believe no reliable scientific evidence supports the benefit of this formulation against COVID-19. [2] NitaNaturale has taken the initiation to jot down all the scientific journals’ published article details to uncover the possible treatment benefits of herbal ingredients present in AYUSH 64 against COVID-19.

Central Council for Research in Ayurvedic Sciences (CCRAS) in collaboration with the Ministry of AYUSH, Govt. of India has launched a poly-herbal formulation, AYUSH–64 to treat malaria. In 1980, CCRAS has also patented this through National Research Development Corporation after evaluating the safety and efficacy of AYUSH–64 (Patent number 152863). [3, 4]

Clinical Trial details of AYUSH-64

Two human trials had performed to check the efficacy of AYUSH–64 as an anti-malarial drug. Initially, a generalized clinical trial designed had been made to evaluate the anti-malarial efficacy of AYUSH 64. In this study, 1442 positive malaria cases were enrolled at different research institutes and the Center of The Council located in different regions of India. The obtained study result found 89% treatment response that is comparable with Chloroquine and Primaquine (two most commonly used anti-malarial drugs). Later, a double-blind clinical trial was conducted on 178 malaria patients. The study result reported 95.4% drug efficacy. Both of these study findings reported no side effect or toxicity history with the prescribed dose. AYUSH–64 specifically acts against Plasmodium vivax and less efficaciously against Plasmodium falciparum. Plasmodium vivax and Plasmodium falciparum are two common human malaria parasites. [3]

However, another animal research result observed that AYUSH–64 not efficacious against P. berghei, P. yoelii nigeriensis, P. cynomolgi B, and P. knowlesi, four other malaria parasites. [5]

A pilot study had conducted between June 2018 and July 2019 at Raja Ramdeo Anandilal Podar Central Ayurveda Research Institute for Cancer, Mumbai for CCRAS. This trial aimed to evaluate the safety and efficacy of AYUSH 64 in clinically diagnosed Influenza-like illness (ILI). The study author concluded that AYUSH 64 along with standard care was safe and effective against ILI. This formulation also speeds up recovery. Researchers of this study also expected that this poly-herbal formulation might act as an adjuvant therapy with standard care for treating other viral infections that increase body temperature (fever). [6]

Benefits of each of the herbal ingredient present in AYUSH- 64

Composition

Each AYUSH- 64 tablet contains

Saptaparna(Alstonia scholaris Br.) bark aqueous extract 100 mg
Katuki(Picrorhiza kurroa Royle ex. Benth) root extract 100 mg
Kiratatikta (Swertia chirata Karst) whole-plant extract 100 mg
Kuberaksha(Caesalpinia crista ) seed powder 200 mg

Dose as an antimalarial drug

Adults need to take 4 tablets (500 mg per tablet) thrice a day for 5 to 7 days
Children should take 2 tablets thrice a day for 5 to 7 days [3]

Saptaparna Bark

The botanical name of saptaparna or ‘devil’s tree’ is Alstonia scholaris. Cutting off this plant bark releases milky latex. Traditionally the bark of this tree was used for treating malaria fever. The bark extract is also useful as an antiplasmodial, immune-stimulant, hepatoprotective, and anticancer agent. In Ayurveda, the overnight soaked bark of this plant uses to control blood sugar levels. [7]

Based on these traditional uses, many scientific research studies had performed. Most of the study findings reported positive results of these traditional therapeutic applications. Researchers found Saptaparna plant containing alkaloids were also effective against broncho-constriction and an effective anti-tussive remedy. [7] Evidence also supports that Saptaparna bark has antimicrobial property. [8]

Herbal researchers reported that the oral dose limit of this bark extract is 2 000 mg/kg body weight. Therefore, administration within this dose limit does not cause any side effects. [9]

Source: https://www.researchgate.net/publication/287720380_A_phytopharmacological_review_of_Alstonia_scholaris_A_panoramic_herbal_medicine

Katuki root extract

Picroside I and Picroside II, cucurbitacins, and phenolic components of Katuki root extract cure numerous illnesses such as fever, liver problems, spleen disorder, and asthma. [10]

Source: https://www.researchgate.net/publication/318984001_A_REVIEW_ON_MEDICINALLY_IMPORTANT_SPECIES_OF_PICRORHIZA_A_REVIEW_ON_MEDICINALLY_IMPORTANT_SPECIES_OF_PICRORHIZA

It has been found that Katuki root extract inhibits allergen and platelet-activating factor (PAF)-induced bronchodilator. Thus, this herbal ingredient is effective in reducing the severity and frequency of asthma. This herb also can lower blood sugar levels. Apocynin is a phytochemical present in Katuki root extract. This phytochemical inhibits thromboxane A2 production to control inflammatory pathways to prevent inflammation. [11]

Kiratatikta whole-plant extract

Different Ayurveda formulations such as AYUSH 64, Diabecon, Mensturyl syrup, and Melicon V ointment contain this herbal ingredient. This medicinal plant has antipyretic, hypoglycaemic, antifungal, and antibacterial properties. Traditionally, a decoction of this herb is used for different therapeutic purposes due to its antimalarial, antifatigue, anti-inflammatory, anthelmintic, antifungal, antibacterial, antidiarrheal, anti-aging, cardio-stimulant, cardio-protectant, hepato-protective, hypoglycemic, and blood pressure, and blood sugar-lowering effects. Several scientific research studies have also evaluated the medicinal properties of Kiratatikta plant extract. No significant side effects were observed in any of the researches. [12]

Swertia chirayita. (A) Seeds, (B) Plant in nature, (C) Root of a mature plant, (D) Dry plant material, (E) High shoot multiplication in a plant tissue culture system.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709473/

Kuberaksha seed powder

Caesalpinia crista Linn. (C. crista), is the botanical name of this plant. This plant is commonly known as Fever nut. The led-colored, oblong-shaped seeds of this plant are 1.3 cm long. One or two seeds are present in one pod. Kuberaksha seed kernels are traditionally used to treat intermittent fever, asthma, and colic. An animal research study showed the antipyretic property of Kuberaksha seed powder and the effect is comparable with paracetamol. An in-vitro study conducted in Indonesia and Myanmar reported that diterpenes present in Kuberaksha have anti-malarial efficacy. [13] Kuberaksha seed powder also has adaptogenic properties, along with antibacterial, antifungal, and antiviral effects. In addition to these, multiple scientific research studies reported that the Kuberaksha seed has anti-diabetic, cardio-protective, and antioxidant properties. [14]

Kuberaksha seed

Source: https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/caesalpinia

How composition of AYUSH 64 effective against COVID-19?

Fever is the most common symptom of COVID-19. [15] Clinicians reported that the fever, dry cough, dyspnea, and fatigue associated with COVID-19 could turn to pneumonia and acute respiratory distress syndrome in severely affected patients. Advanced age, ischemic and congestive heart disease, hypertension, diabetes, and chronic obstructive pulmonary disease (COPD) are the most significant causes of COVID-19 associated death. [16] Asthma patients have a higher risk to develop severe COVID-19 symptoms. [17]

The poly-herbal composition of AYUSH 64 is effective in the treatment against fever. Different scientific researchers concluded from their research works that every ingredient of this formulation got antipyretic properties. Medical researchers have expected that anti-PAF activity could inhibit the activation of human mast cells that largely present in the lungs. These mast cells may have a contribution to COVID-19 severity. Mast cells induce inflammatory mediators release that increases the risk of the severe acute respiratory syndrome (SARS) associated with COVID-19. Researchers also assumed that anti-PAF activity along with anti-inflammatory action of some natural ingredients could act as a prophylactic treatment against COVID-19. [18] It has already been mentioned that AYUSH 64 containing Katuki root extract inhibits PAF and induces bronchodilation. Kiratatikta whole-plant extract of this formulation also has significant anti-inflammatory properties. These herbal ingredients may also reduce post-Covid complications like increased blood pressure, blood sugar, anxiety, and different metabolic disorders.

Research evidence

A research study showed that human coronaviruses (HCoVs) are commonly associated with ILI [19], though HCoVs have different strains. A pilot trial result found that administration of AYUSH 64 with standard care could decline ILI symptoms with a faster recovery rate than those only in standard care. This early recovery may happen because herbal ingredients present in AYUSH 64 help to restore metabolism and strengthen the immune status. This trial result also found that AYUSH 64 is a well-tolerated preparation. [6]
Another ongoing randomized trial is also going on under CSIR to evaluate the efficacy of AYUSH 64 as an adjunct treatment to standard of care. [20] We hope soon this study will be completed and the test result will be declared.

Indication

Experts suggest that the AYUSH- 64 is effective against mild to moderate COVID-19 cases with initial symptoms like fever, cough, malaise, headache, body ache, nasal congestion, nasal discharge, etc. Asymptomatic COVID-19 patients who have confirmed their disease through RT-PCR can preferably start AYUSH- 64 within 7 days of diagnosis of the condition. [21]

Dose

Two tablets of 500 mg twice daily are recommended for prophylactic treatment.

Experts suggest that AYUSH-64 be continued for a minimum of 14 days. However, if required, one can take this medicine up to 12 weeks based on the advice from a qualified AYUSH practitioner. Pregnant and lactating mothers should not take this formulation as yet now no studies are performed on them. [21]

NitaNaturale does not claim that AYUSH-64 is an effective treatment for COVID-19. But this blog can help readers to unfold the therapeutic benefits of each herbal ingredient present in AYUSH-64.

References

Black seed and honey a novel natural remedy for Coronavirus infection

Nita — Wed, 25 Nov 2020 06:36:54 +0000

Physically we unlocked ourselves from the lockdown of the COVID-19 pandemic by accepting the social distancing and isolation for controlling the disease transmission. But these generalized measures unable to control the addition of new cases. WHO Coronavirus Disease (COVID-19) Dashboard displayed the current global situation of confirmed cases (55,326,907) and death rate (1,333,742) on 18th November 2020. [1] I do not want to generate fear among readers by presenting this data, but surely want to alert them about the necessity of boosting immunity. Many of us may use different natural remedies during this pandemic to improve our immune system functioning. But you may not know that the zed black colored tiny triangular shaped black seeds in combination with honey are an excellent natural remedy to fight against Coronavirus infection.

Evidential background for the recommendation

A mixture of Black seed and honey has the potential benefits to prevent as well as reduce the severity of Coronavirus infection. The Hindu ePaper published an article on their BusinessLine Page On 9th November 2020. The report mentioned that a multicentre randomized, controlled clinical trial showed a combination of 1 gm/kg/day of honey and 80 mg/kg/day of Black seed (scientifically known as Nigella sativa) treatment for 13 days was effective to clear viral load and alleviated symptoms of Coronavirus infection. This study result found that anti-diabetic, anti-hypertensive, cardio-protective, and broncho-dilatory properties of honey and the Black seed mixture could reduce the mortality rate among high-risk patients who had diabetes, hypertension, cardiac disorders, or asthma. [2] Based on this promising study result, Intas Pharmaceuticals Limited has recently launched its new patented tablet formulation, Thymotas. Thymoquinone and honey are the two primary ingredients present in Thymotas formulation.[3] Your Black seed is a rich source of Thymoquinone.

Why we have to depend on black seed and honey mixture or such natural remedies to deal with the Coronavirus pandemic?

Research and development departments of different Pharma companies are working hard to speed up to launch of vaccines as well as specialized treatment for COVID-19 infection as early as possible. But no licensed vaccine or specific treatment for coronavirus infection till now available in the market. In such conditions, nature offers a new remedy. A mixture of Black seed and honey to strengthen our immune system to fight against Coronavirus infection.

How a combination of black seed and honey is effective against Coronavirus infection?

Both Black seed and honey are common traditional remedies used in different airway disorders such as throat infections, bronchitis, flu, and pneumonia. [4,5] Moreover, Black seed oil is a useful treatment for chronic pain symptoms such as headache and back pain, etc. Therefore, these traditional applications indicate these two natural ingredients have the potential to use in COVID-19 infection. The scientific explanation is a little detailed. But this detailed explanation helps readers to understand why this combination they should include in their regular regimen during this pandemic.

The combination of bioactive phytochemicals presents in black seeds and the unique nutritional composition of honey not only an effective remedy to boost immunity for preventing Coronavirus infection but also has the potential to reduce the risk of severity of the symptoms of Coronavirus infected patients. Research experts recommended black seed containing Thymoquinone in combination with honey can be used as an adjuvant therapy with conventional standard prescribed treatment to obtain better therapeutic outcomes against Coronavirus infection. [3]

Thymoquinone is the chief bioactive phytochemicals present in Black seeds. Along with Thymoquinone, thymohydroquinone, thymol, dithymoquinone, carvacrol, and β-Pinene present in the Black seed are worked together and exert antioxidant, antimicrobial, anti-diabetic, antihypertensive, and reno-protective effects. All these therapeutic benefits are essential treatment approaches for Coronavirus infected patients. [5] Whereas, the flavonoids and polyphenolic compounds present in honey may impart antimicrobial, antiviral, and antioxidant effects. [6]

Medicinal Property	Mechanism of Action	Research Evidence
Boosts immunity and reduces viral load	Black seed increases CD4 count and production of interferon- (INF-) gamma with and also activates T cell functioning. [5] Honey has attributed antiviral effect due to its osmotic effect, naturally low pH, and presence of bioactive natural compounds. [4] Flavonoids and its other derivatives present in honey exert a broad-spectrum antiviral effect. [4] Honey targets the 3‐chymotrypsin‐like cysteine protease enzyme of SARS‐CoV, which is one of the most promising targets for drug discovery against coronaviruses. [4]	The clinical trial result reported Black seed is effective against hepatitis C virus. Treatment with Black cumin seed oil exerts symptomatic relief and improves laboratory parameters. [5] The antiviral effect of Black seed is effective against multiple viral infections, such as murine cytomegalo virus infection, avian influenza (H9N2), Chistosoma Mansoni Infection, PPR virus, Broad bean mosaic virus, HIV, Hepatitis C Virus, Zucchini Yellow Mosaic Virus, and Papaya Ring Spot Virus. [7] Honey inhibits the viral replication of the influenza virus due to its virucidal effects. It synergistically interacted with the other antiviral medicines. [4] Apart from the influenza virus, honey is also effective against human respiratory syncytial, human rhinovirus, human metapneumovirus, parainfluenza, and betacoronavirus. [4] Although the antiviral effect of honey against the novel coronavirus (SARS‐CoV‐2) has not been confirmed yet, [4] but a combination of honey and Black seed is effective to prevent and reduce the severity of coronavirus. [2] The combination of Black seed and honey is also offered protection against HIV transmission from pregnant women to the fetus. [5] Recently, a trial result confirmed that a combination of Black seed and honey is also offering protection and reduce the severity of COVID-19. [2]
Bronchodilator	Thymoquinone‚ the main component of Black seed reduces tracheal contraction, and anti-inflammatory effect reduces bronchial inflammation. The antispasmodic effect relaxes the smooth muscles present in the airways. [5] Honey is a natural demulcent that soothes cough symptoms. It increases cytokine release and provides apparent benefit in the common cold. [9]	A preclinical research result supported that Black Seed has a preventive effect against pulmonary fibrosis and inflammation. [8] A clinical trial result concluded that honey is a cost-effective cough treatment. [9]
Antioxidant property	Black seed consumption increases antioxidant enzymes like erythrocyte glutathione peroxidase and superoxide dismutase activity and also reduces free radicals (plasma malondialdehyde). [5] Phenolic and flavonoid components of honey responsible for the antioxidant property. [6]	A human trial result reported that consumption of Black seed oil for eight weeks significantly diminishes the superoxide dismutase free radical (SOD) level. [5] The strong antioxidant property of honey improves the nutrition quality and provides positive benefits for human health. [6]
Antidiabetic property	Black seed intake improves the pancreatic β-cells degeneration, reduces pancreatic inflammation, and congestion. [5] Honey containing oligosaccharides as well as Palatinose-based balanced formula improve glycaemic response in diabetic patients. [10]	A human trial result reported that administration of black seed oil with a dose of 3ml per day for 20 days showed a marked reduction of random blood sugar and glycated hemoglobin A1c levels. [5] Multiple clinical studies showed positive antidiabetic outcomes with honey supplementation. [10]
Antihypertensive	Black seed and its active component, thymoquinone can act as a calcium channel blocker and increase urine output due to its potent antioxidant property. [5] The antioxidant property of Honey regulates oxidative stress and effective to control blood pressure. [11]	A human trial result showed that Black Seed oil significantly lowers systolic, diastolic, and mean arterial blood pressure along with heart rate, total cholesterol, and low-density lipoprotein cholesterol level. [5] Honey supplementation reduces elevated systolic blood pressure levels. [11]
Reno-protective	Antioxidant, anti-inflammatory, and antitoxic properties of Black seed and its phytochemical thymoquinone help to maintain kidney function. [12] Better management of oxidative stress by supplementation with honey gives kidney protection. [11]	The pre-clinical trial result showed a positive benefit of Black seed on kidney tissue. [12] Pre-clinical research showed the positive benefits of honey supplementation. [11]

I hope you can understand now why NitaNaturale recommends you to add a combination of black seeds and honey. The antiviral, broncho-dilatory property, broad-spectrum antioxidant property, and regulating or boosting immune functioning. Along with improving the possible comorbid conditions like regulating blood sugar, pressure, and kidney functioning of the combination of black seeds and honey indicate that we can use this combination as a self-care treatment against SARS-CoV-2. [3]

Tips to use Black seed and honey

I hope you use the whole Black seed in your kitchen. Whole Black seed is a common flavoring spice often used for seasoning purposes. Whole Black seed is completely safe and does not have any side effects. According to the different research studies, I have found that Black seed oil has optimal therapeutic benefits in comparison with Black seed powder. Therefore, it is better to intake Black seed oil than the whole black seed to gain therapeutic benefits. But NitaNaturale will give additional tips for those who use the whole Black seed as a kitchen ingredient and do not want to spend extra to buy Black seed oil.
Take a teaspoon of Black seed and ground them freshly. Add the powder into a small cup of boiling water. Close the lid and wait for a minute. Then put off the flame. After 7 to 10 minutes, add one teaspoon of honey and enjoy the warm drink every morning. This small lifestyle change may give you protection not only from Covid-19 but helps to prevent other microbial infections, normalize blood glucose, cholesterol, and can also regulate blood pressure.
I have committed to explaining all the science behind the tips given in the NitaNaturale. Therefore, I just wanted to add that instead of using Black seed oil, fresh Black seed powder has enough efficacy to fight against Covid-19. I found during my research that a human trial result confirmed that boiled extract of Black seed had a potent bronchodilatory effect. [13] Another research also confirmed that ground black seed has an antimicrobial effect. [14] Even Black seed powder provides better plasma lipid control. [15]
Select Arabian origin-based organic Black seed, which is better compared to other origins in respect of therapeutic value. [16] Another important tip is to use Manuka honey, which has better therapeutic benefits than other varieties. [17]

What precautionary measures essential to know about Black seed and honey?

If any individual has an allergic tendency towards Bee products, then honey may not be a suitable option for them. During pregnancy, Black seed intake is not recommended as it can delay uterine contraction. Individuals who are under blood clotting medications should not take Black seed without consulting with the doctor. [18]

References

Turmeric: A preventive remedy for Coronavirus infection

Nita — Tue, 29 Sep 2020 14:36:44 +0000

The Coronavirus pandemic brings a new normal. Along with several changes, turmeric shifts its place from the kitchen cabinet to the medicine shelf in many houses, because not only Asian countries, but turmeric is globally accepted as an effective treatment against Coronavirus.

Recently two journals published articles reviewed the efficacy of turmeric against Coronavirus and the optimistic reports insist me to start my blogging carrier to highlighting the facts with my readers. However, the authors of these research reports concluded that detailed clinical investigation further needed to establish its efficacy statistically.

Before I emphasize the benefits of turmeric against Coronavirus infections, I want to share some general information about Coronavirus infections. Severe acute respiratory diseases are the main worry about the coronavirus. Apart from the lung problem, many medical professionals explain coronavirus targets other vital organs including the heart and kidney functioning also. [1] The COVID-19 follows fast mutation and that’s the reason to develop resistance against pre‐existing antiviral medications. This makes the difficulty to treat Coronavirus infections and multiple failures occur in a conventional treatment process. [1]

Turmeric is one of the most researched herbal ingredients and much research evidence has proven the therapeutic benefits of curcumin. Curcuma longa is the scientific name of the turmeric. According to the review report published in Phytotherapy Research Journal on 19th May 2020, it has mentioned that turmeric containing curcumin has the potency to acts against Coronavirus due to its multiple anti-viral mechanisms of actions. [1] This review report also mentioned that the promising benefits of turmeric against damage to the vital organs. [1] Similar scientific-based evidence you will also found in an article published by the Clinical and Experimental report dated 1st July 2020 under the titled ‘Potential benefits of turmeric in COVID-19’. [2]

The US food and drug administration (FDA) has also approved curcumin after reviewing more than 300 human trial results. All these results reported that curcumin has beneficial protective effects against multiple disorders including inflammatory conditions, cardiovascular problems, pulmonary disease, neurological disorder, metabolic diseases, liver problems, and cancers. [1] The secret element of turmeric, i.e. curcumin was discovered by Vogel and Pelletier in the Harvard College laboratory almost two centuries ago. Turmeric contains 2- 5% of curcumin along with other phytochemicals. [3, 4] Along with curcumin, other multiple phytochemicals present in this golden spice can manifest these activities uniquely, additively, or synergistically with curcumin. [5]

How turmeric effective against Coronavirus?

NitaNaturale always insists readers to know in detail for wholehearted acceptance of health-related substances in their life. So that no further confusion can create any dilemma or non-compliance about your treatment or lifestyle measure decision. Following the mechanism of actions of turmeric makes it a promising herbal remedy against Coronavirus.

Turmeric has antiviral property

Turmeric containing phytochemicals interacts with the viral replication cycle by targeting DNA polymerase along with other various essentials molecular requirements for virus replication. Thus, Turmeric restricts viral multiplication. The antiviral effects of turmeric act against various viruses like parainfluenza virus type 3, herpes simplex virus, respiratory syncytial virus, etc. Turmeric can block the virus entrance into our immune system and also hinders virus budding by modifying the surface structure of the virus so that they unable to bind with the target receptor in our physiological system. [1]

Turmeric restricts Coronavirus entry

Researchers have shown that curcumin present in turmeric can slow down viral load by altering surface protein structure in viruses and blocking the entry of viruses to the cell. In childhood, we read about a virus, a single-cell living organism, and does not contain all the required enzymes for replication. After invading, the virus into a host cell, they use the cellular mechanism of the host body for their reproduction. The antiviral agents usually restrict the replication of viruses, so that they cannot penetrate healthy cells and restrict them only in the infected cells. Thus, the infection cannot spread and turns to disease. The antiviral property of turmeric targets the penetration ability of a virus and also restricts the supply of essential cellular components required for viral replication. [1]

Recent researchers estimated that Coronavirus bind with the Angiotensin‐converting enzyme 2 (ACE2) receptor present in our body and spread the infection to different vital organs by spiking the glycoprotein. But the administration of curcumin can bind with the ACE2 receptor and restrict the entry of Coronavirus. [1]

NitaNaturale recommends readers use turmeric as a prophylactic treatment for viral infections. This means you need to take turmeric before start any infection and continue to take throughout the incubation period of the germ.

Turmeric cease coronavirus load

Restriction of viral replication is one of the potential therapeutic strategies to reduce the viral load. Laboratory-based research results showed that curcumin can reduce the viral load by inhibiting SARS‐CoV replication. Curcumin can break RNA synthesis to stop viral replication. [1]

Turmeric slows down coronavirus infection

Viral protease of Coronavirus can impede immune response. Turmeric containing phytochemicals like curcumin can inhibit viral protease by following molecular docking. This mechanism of action of curcumin reduces the binding energies of Coronavirus and inhibit the steady growth of infection. [1]

Turmeric reduces fatality of Coronavirus infection

Different types of interferon (IFN) mediated immune responses can act against viral infection. But the reduction of interferon production in our immune system can increase the fatality of coronavirus, which might be one of the reasons for the higher mortality rate among elderly patients. I have researched different journal papers. And I got the information that turmeric containing curcumin administration could increase the production of IFN and activate our innate immune responses against the fatality of Coronavirus infection by reducing the reproduction of this virus. But early intervention is very important to get this benefit. Therefore, I suggest you start taking turmeric regularly until the pandemic does not over. [1]

Turmeric protects against Coronavirus induced lung disorders

Coronavirus stimulates the secretion of different inflammatory mediators like cytokines into the endothelial cells of the blood vessels present in the pulmonary system. Turmeric has a potent anti-inflammatory effect due to the presence of curcumin in it, which downregulates the cytokines and other inflammatory mediators released in lung infections and reduces the severity. [1] A research result already reported that curcumin administration had the potentiality to act against recurrent respiratory tract infections due to its immune-modulatory effects. [6]

Coronavirus induced lung fibrosis is a devastating outcome of COVID‐19 infection leads to acute respiratory distress syndrome. Curcumin interacts with the NF‐кB pathway and prevents TGF‐ß overexpression, which is the main culprit of lung fibrosis development.

Water lodging in the lung tissue or pulmonary edema is another cause of COVID‐19 infection severity. Animal research results reported that the anti-inflammatory property of curcumin could be used as a prophylactic treatment to reduce the risk of fluid accumulation in the lungs under hypoxia (inadequate oxygen supply in the lungs). [1]

Turmeric safeguarding the cardiovascular system against Coronavirus infection

ACE2 enzyme plays a vital role in cardiac functioning. Coronavirus infection spikes ACE2 enzyme activity. The lungs, heart, and kidney are the organs where the ACE2 receptor is present. Suppression of ACE2 activity can cause cardiac dysfunction. But curcumin present in turmeric has a specific role in angiotensin receptor, which significantly controls blood pressure and improves cardiac fibrosis. Besides this, the anti-inflammatory property of turmeric also decreases the risk of cardiac inflammation. [1]

Turmeric prevents Coronavirus associated kidney damage

Some COVID‐19 infected patients also have reported kidney damage. Turmeric can improve renal blood flow by correctly modulating angiotensin receptor functioning. Its anti-inflammatory property also provides potential benefits in the treatment of COVID‐19 associated kidney injury. [1]

Turmeric inhibits oxidative stress enhancement due to Coronavirus infection

Coronavirus infection generates reactive oxygen species (ROS), which also damages lung tissue. Turmeric has a potent antioxidant property which up‐regulates glutathione, the natural antioxidant present in our body, and neutralizes the excess burden of ROS, and helps to reduce the oxidative stress in the lungs. [1]

Tips to Get Optimum Benefits of Turmeric

Intake of fresh turmeric powder mixing with fat like olive oil, flaxseed oil, coconut oil, coconut milk, or fish oil for faster dissolving curcumin (curcumin is fat-soluble). Thus, curcumin absorption becomes faster in the blood.
Drink hot turmeric preparations, because heat enhances the bioavailability of curcumin by increasing its solubility in gastrointestinal fluid. I recommend turmeric milk at bedtime to heal your body naturally.
Turmeric is safe to use in a dose between 6–7 g/day orally. [2] You can divide these dose into multiple segments and can enjoy different turmeric recipes so that your taste buds cannot become dull. It is an easy way to maintain long-term compliance for including herbs in your daily diet.
Turmeric latte is one of the health-trendy recipes. Try to prepare the preparation in your kitchen.
Instead of taking turmeric alone, mix it with black pepper, which is the natural source of piperine.

What precautionary measures essential to know about turmeric?

Excessive doses of turmeric can cause nausea, vomiting, or other gastrointestinal problems. The dose of turmeric must be reduced if you use a combination of turmeric and black pepper. This herbal combination increases the bioavailability of phytochemicals present in turmeric. A combination of 2 g of curcumin with 5 mg of piperine displayed three times enhancement of bioavailability. [7]

Note: Blogs under NitaNaturale contain some medical terms and concepts, which you may not know in detail. For better understanding, readers can feel free to contact me by filling the form under the contact section.

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